Models and mechanisms of repeat expansion disorders: a worm’s eye view
نویسندگان
چکیده
منابع مشابه
RNA-mediated neurodegeneration in repeat expansion disorders.
Most neurodegenerative disorders are thought to result primarily from the accumulation of misfolded proteins, which interfere with protein homeostasis in neurons. For a subset of diseases, however, noncoding regions of RNAs assume a primary toxic gain-of-function, leading to degeneration in many tissues, including the nervous system. Here we review a series of proposed mechanisms by which nonco...
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Determinants of cell polarity orient the behaviour of many cell types during development. Pioneering genetic screens in yeast, worms and flies have identified key polarity determinants that are evolutionarily conserved across the animal kingdom. Recent work in these three model organisms has combined computer modelling with experimental analysis to reveal the molecular mechanisms that drive the...
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Background & Aims: Nearly 30 hereditary disorders in humans result from an increase in the number of copies of simple repeats in genomic DNA, including fragile X syndrome, myotonic dystrophy, Huntington’s disease, and Friedreich’s ataxia. One the most frequently occurring types of mutation is trinucleotide repeat expansion. The present study was conducted with the aim of investigating the cause...
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Inam Neuroscience Research Center, Department of Neurology, Sanbon Medical Center, College of Medicine, Wonkwang University, Gunpo, Korea The majority of neurodegenerative dementias are thought to result primarily from the misfolding, aggregation and accumulation of proteins which interfere with protein homeostasis in the brain. Some of them are caused by the expansion of unstable nucleotide re...
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1. Introduction The communal nature of the Internet exposes organizations and home computer users to a multitude of worms, viruses, and other malicious software (malware) threats such as spyware and Trojan horses. Viruses are program fragments attached to normal programs or files that hijack the execution control of the host program to reproduce copies of the virus. Worms are automated self-rep...
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ژورنال
عنوان ژورنال: Journal of Genetics
سال: 2018
ISSN: 0022-1333,0973-7731
DOI: 10.1007/s12041-018-0950-8